This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Epithelial cells form continuous coverings over all surfaces in the human body and have distinct top and bottom sides, but they can sometimes transform to function more like mesenchymal cells, losing their tight connections to adjacent cells and gaining mobility. This process, known as epithelial–mesenchymal transition (EMT), can be beneficial for wound healing and embryonic development but can also promote the progression of cancer. Research suggests that acetylation, or the addition of an acetyl group to another molecule, may play an important role in EMT and that this process is controlled by the activity of lysine acetyltransferase enzymes. In particular, the acetylation of specific histones, proteins that provide structural support to chromosomes and can regulate gene activity, could promote EMT. But recent studies have also shown that the acetylation of non-histone proteins could also be involved. For example, the acetylation of the protein E-cadherin has been found to accelerate EMT in cancer cells..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 05/18/2022
